Top 10 across passing, rushing, and receiving. Efficiency leaderboards require minimum attempts so backups don't top a small-sample list.
| 1 | Matthew StaffordLAR | 4,707 46 TD · 8 INT |
| 2 | Jared GoffDET | 4,564 34 TD · 8 INT |
| 3 | Dak PrescottDAL | 4,552 30 TD · 10 INT |
| 4 | Drake MayeNWE | 4,394 31 TD · 8 INT |
| 5 | Sam DarnoldSEA |
| 1 | James CookBUF | 1,621 309 att · 12 TD |
| 2 | Derrick HenryBAL | 1,595 307 att · 16 TD |
| 3 | Jonathan TaylorIND | 1,585 323 att · 18 TD |
| 4 | Bijan RobinsonATL | 1,478 287 att · 7 TD |
| 5 | De'Von AchaneMIA |
| 1 | Jaxon Smith-NjigbaSEA | 1,793 119 rec · 10 TD |
| 2 | Puka NacuaLAR | 1,715 129 rec · 10 TD |
| 3 | George PickensDAL | 1,429 93 rec · 9 TD |
| 4 | Ja'Marr ChaseCIN | 1,412 125 rec · 8 TD |
| 5 | Amon-Ra St. Brown |
| 4,048 25 TD · 14 INT |
| 6 | Trevor LawrenceJAX | 4,007 29 TD · 12 INT |
| 7 | Caleb WilliamsCHI | 3,942 27 TD · 7 INT |
| 8 | Bo NixDEN | 3,931 25 TD · 11 INT |
| 9 | Justin HerbertLAC | 3,727 26 TD · 13 INT |
| 10 | Baker MayfieldTAM | 3,693 26 TD · 11 INT |
| 1 | Matthew StaffordLAR | 46 4,707 yds |
| 2 | Jared GoffDET | 34 4,564 yds |
| 3 | Drake MayeNWE | 31 4,394 yds |
| 4 | Dak PrescottDAL | 30 4,552 yds |
| 5 | Trevor LawrenceJAX | 29 4,007 yds |
| 6 | Caleb WilliamsCHI | 27 3,942 yds |
| 7 | Justin HerbertLAC | 26 3,727 yds |
| 8 | Baker MayfieldTAM | 26 3,693 yds |
| 9 | Josh AllenBUF | 25 3,668 yds |
| 10 | Bo NixDEN | 25 3,931 yds |
| 1 | Drake MayeNWE | 72.0% 354/492 |
| 2 | Mac JonesSFO | 69.6% 201/289 |
| 3 | Brock PurdySFO | 69.4% 197/284 |
| 4 | Josh AllenBUF | 69.3% 319/460 |
| 5 | Kyler MurrayARI | 68.3% 110/161 |
| 6 | Jared GoffDET | 68.0% 393/578 |
| 7 | Daniel JonesIND | 68.0% 261/384 |
| 8 | Sam DarnoldSEA | 67.7% 323/477 |
| 9 | Tua TagovailoaMIA | 67.7% 260/384 |
| 10 | Spencer RattlerNOR | 67.7% 174/257 |
| 1,350 238 att · 8 TD |
| 6 | Kyren WilliamsLAR | 1,252 259 att · 10 TD |
| 7 | Jahmyr GibbsDET | 1,223 243 att · 13 TD |
| 8 | Christian McCaffreySFO | 1,202 311 att · 10 TD |
| 9 | Javonte WilliamsDAL | 1,201 252 att · 11 TD |
| 10 | Saquon BarkleyPHI | 1,140 280 att · 7 TD |
| 1 | Jonathan TaylorIND | 18 1,585 yds |
| 2 | Derrick HenryBAL | 16 1,595 yds |
| 3 | Josh AllenBUF | 14 579 yds |
| 4 | Jahmyr GibbsDET | 13 1,223 yds |
| 5 | Josh JacobsGNB | 13 929 yds |
| 6 | James CookBUF | 12 1,621 yds |
| 7 | Zach CharbonnetSEA | 12 730 yds |
| 8 | Javonte WilliamsDAL | 11 1,201 yds |
| 9 | Christian McCaffreySFO | 10 1,202 yds |
| 10 | Kyren WilliamsLAR | 10 1,252 yds |
| 1 | Justin HerbertLAC | 6.00 83 att |
| 2 | De'Von AchaneMIA | 5.67 238 att |
| 3 | Jaxson DartNYG | 5.66 86 att |
| 4 | James CookBUF | 5.25 309 att |
| 5 | Derrick HenryBAL | 5.20 307 att |
| 6 | Josh AllenBUF | 5.17 112 att |
| 7 | Bijan RobinsonATL | 5.15 287 att |
| 8 | Blake CorumLAR | 5.14 145 att |
| 9 | TreVeyon HendersonNWE | 5.06 180 att |
| 10 | J.K. DobbinsDEN | 5.05 153 att |
| 1,401 117 rec · 11 TD |
| 6 | Trey McBrideARI | 1,239 126 rec · 11 TD |
| 7 | Zay FlowersBAL | 1,211 86 rec · 5 TD |
| 8 | Chris OlaveNOR | 1,163 100 rec · 9 TD |
| 9 | Jameson WilliamsDET | 1,117 65 rec · 7 TD |
| 10 | Nico CollinsHOU | 1,117 71 rec · 6 TD |
| 1 | Davante AdamsLAR | 14 789 yds |
| 2 | Amon-Ra St. BrownDET | 11 1,401 yds |
| 3 | Dallas GoedertPHI | 11 591 yds |
| 4 | Tee HigginsCIN | 11 846 yds |
| 5 | Trey McBrideARI | 11 1,239 yds |
| 6 | Jaxon Smith-NjigbaSEA | 10 1,793 yds |
| 7 | Puka NacuaLAR | 10 1,715 yds |
| 8 | Chris OlaveNOR | 9 1,163 yds |
| 9 | George PickensDAL | 9 1,429 yds |
| 10 | Jauan JenningsSFO | 9 643 yds |
| 1 | Puka NacuaLAR | 129 166 tgt |
| 2 | Trey McBrideARI | 126 169 tgt |
| 3 | Ja'Marr ChaseCIN | 125 185 tgt |
| 4 | Jaxon Smith-NjigbaSEA | 119 163 tgt |
| 5 | Amon-Ra St. BrownDET | 117 172 tgt |
| 6 | Christian McCaffreySFO | 102 129 tgt |
| 7 | Chris OlaveNOR | 100 156 tgt |
| 8 | George PickensDAL | 93 137 tgt |
| 9 | Wan'Dale RobinsonNYG | 92 140 tgt |
| 10 | Kyle PittsATL | 88 118 tgt |