Top 10 across passing, rushing, and receiving. Efficiency leaderboards require minimum attempts so backups don't top a small-sample list.
| 1 | Matthew StaffordLAR | 1,794 11 TD · 6 INT |
| 2 | C.J. StroudHOU | 1,714 9 TD · 1 INT |
| 3 | Jordan LoveGNB | 1,684 11 TD · 4 INT |
| 4 | Dak PrescottDAL | 1,639 10 TD · 5 INT |
| 5 | Kirk CousinsLVR |
| 1 | Kenneth Walker IIIKAN | 665 106 att · 6 TD |
| 2 | Bijan RobinsonATL | 641 111 att · 4 TD |
| 3 | James CookBUF | 627 117 att · 6 TD |
| 4 | Derrick HenryBAL | 534 130 att · 7 TD |
| 5 | Jahmyr GibbsDET |
| 1 | Jaxon Smith-NjigbaSEA | 717 49 rec · 7 TD |
| 2 | Chris OlaveNOR | 580 43 rec · 2 TD |
| 3 | CeeDee LambDAL | 577 48 rec · 4 TD |
| 4 | Drake LondonATL | 550 31 rec · 0 TD |
| 5 | Christian WatsonGNB |
| 1,582 14 TD · 5 INT |
| 6 | Bryce YoungCAR | 1,549 11 TD · 2 INT |
| 7 | Josh AllenBUF | 1,504 9 TD · 4 INT |
| 8 | Aaron RodgersPIT | 1,487 12 TD · 5 INT |
| 9 | Jared GoffDET | 1,485 12 TD · 0 INT |
| 10 | Trevor LawrenceJAX | 1,480 14 TD · 4 INT |
| 1 | Trevor LawrenceJAX | 14 1,480 yds |
| 2 | Kirk CousinsLVR | 14 1,582 yds |
| 3 | Brock PurdySFO | 14 1,460 yds |
| 4 | Jared GoffDET | 12 1,485 yds |
| 5 | Tyler ShoughNOR | 12 1,443 yds |
| 6 | Aaron RodgersPIT | 12 1,487 yds |
| 7 | Bryce YoungCAR | 11 1,549 yds |
| 8 | Joe BurrowCIN | 11 1,361 yds |
| 9 | Jordan LoveGNB | 11 1,684 yds |
| 10 | Drake MayeNWE | 11 1,463 yds |
| 1 | Joe BurrowCIN | 71.4% 135/189 |
| 2 | Brock PurdySFO | 69.6% 119/171 |
| 3 | Geno SmithNYJ | 68.9% 122/177 |
| 4 | Kyler MurrayMIN | 68.3% 69/101 |
| 5 | Jared GoffDET | 67.0% 128/191 |
| 6 | Josh AllenBUF | 66.7% 114/171 |
| 7 | Jacoby BrissettARI | 66.7% 156/234 |
| 8 | Patrick MahomesKAN | 66.5% 105/158 |
| 9 | Dak PrescottDAL | 66.3% 163/246 |
| 10 | Matthew StaffordLAR | 65.9% 164/249 |
| 504 105 att · 7 TD |
| 6 | Jonathan TaylorIND | 492 122 att · 7 TD |
| 7 | Jaylen WarrenPIT | 460 84 att · 1 TD |
| 8 | Bucky IrvingTAM | 452 96 att · 2 TD |
| 9 | Chuba HubbardCAR | 426 89 att · 4 TD |
| 10 | Aaron JonesMIN | 410 97 att · 2 TD |
| 1 | Josh AllenBUF | 8 240 yds |
| 2 | Jahmyr GibbsDET | 7 504 yds |
| 3 | Javonte WilliamsDAL | 7 317 yds |
| 4 | Jonathan TaylorIND | 7 492 yds |
| 5 | Derrick HenryBAL | 7 534 yds |
| 6 | Christian McCaffreySFO | 7 350 yds |
| 7 | D'Andre SwiftCHI | 6 398 yds |
| 8 | James CookBUF | 6 627 yds |
| 9 | Kenneth Walker IIIKAN | 6 665 yds |
| 10 | Chuba HubbardCAR | 4 426 yds |
| 1 | Kenneth Walker IIIKAN | 6.27 106 att |
| 2 | Bijan RobinsonATL | 5.77 111 att |
| 3 | Jaylen WarrenPIT | 5.48 84 att |
| 4 | James CookBUF | 5.36 117 att |
| 5 | Kyren WilliamsLAR | 4.91 80 att |
| 6 | Jahmyr GibbsDET | 4.80 105 att |
| 7 | Chuba HubbardCAR | 4.79 89 att |
| 8 | Bucky IrvingTAM | 4.71 96 att |
| 9 | Christian McCaffreySFO | 4.55 77 att |
| 10 | D'Andre SwiftCHI | 4.23 94 att |
| 538 29 rec · 6 TD |
| 6 | Matthew GoldenGNB | 501 30 rec · 3 TD |
| 7 | Malik NabersNYG | 494 41 rec · 2 TD |
| 8 | Davante AdamsLAR | 480 30 rec · 4 TD |
| 9 | Tetairoa McMillanCAR | 471 32 rec · 2 TD |
| 10 | Zay FlowersBAL | 471 32 rec · 2 TD |
| 1 | Jaxon Smith-NjigbaSEA | 7 717 yds |
| 2 | Christian WatsonGNB | 6 538 yds |
| 3 | Amon-Ra St. BrownDET | 5 372 yds |
| 4 | Isaiah LikelyNYG | 5 383 yds |
| 5 | George KittleSFO | 5 337 yds |
| 6 | Mike GesickiCIN | 4 159 yds |
| 7 | Ja'Marr ChaseCIN | 4 289 yds |
| 8 | Parker WashingtonJAX | 4 416 yds |
| 9 | Pat FreiermuthPIT | 4 180 yds |
| 10 | Stefon DiggsWAS | 4 214 yds |
| 1 | Trey McBrideARI | 49 65 tgt |
| 2 | Jaxon Smith-NjigbaSEA | 49 66 tgt |
| 3 | CeeDee LambDAL | 48 69 tgt |
| 4 | Chris OlaveNOR | 43 61 tgt |
| 5 | Malik NabersNYG | 41 61 tgt |
| 6 | Isaiah LikelyNYG | 39 59 tgt |
| 7 | Amon-Ra St. BrownDET | 37 57 tgt |
| 8 | Puka NacuaLAR | 37 52 tgt |
| 9 | Garrett WilsonNYJ | 35 48 tgt |
| 10 | George PickensDAL | 33 52 tgt |