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Week 2 · 2026 Season

Detroit Lions

0-0 · NFC North

at

Buffalo Bills

0-0 · AFC East

Date

Thursday, September 17, 2026

Kickoff

8:15 PM

Location

Highmark Stadium · Orchard Park, New York

Line

—

Heading In · Last 3 Games

Detroit Lions

1-2 · 17.7 PPG · 22.7 OPG
  • W19-16@ CHI
  • L10-23@ MIN
  • L24-29vs PIT

Buffalo Bills

2-1 · 23.3 PPG · 13.7 OPG
  • W35-8vs NYJ
  • L12-13vs PHI
  • W23-20@ CLE

Recent Head-to-Head

Last 5 meetings · DET 0–5 BUF

DateWkResult
2024-12-152024 W15BUF 48–42
2022-11-242022 W12BUF 28–25
2018-12-162018 W15BUF 14–13
2014-10-052014 W5BUF 17–14
2010-11-142010 W10BUF 14–12

Full matchup analysis

11-on-11 depth-chart breakdown, key positional edges, betting splits.