Round 1
| # | Player | Team |
|---|---|---|
| 1 | Myles Garrett DE · Texas A&M · 7 Pro Bowls · 5 All-Pros · 134 games | CLE |
| 3 | Solomon Thomas DE · Stanford · 131 games | SFO |
| 6 | Jamal Adams S · LSU · 3 Pro Bowls · 1 All-Pro · 102 games | NYJ |
| 11 | Marshon Lattimore CB · Ohio St. · 4 Pro Bowls · 108 games | NOR |
| 13 | Haason Reddick LB · Temple · 2 Pro Bowls · 137 games | ARI |
| 14 | Derek Barnett DE · Tennessee · 112 games | PHI |
| 15 | Malik Hooker S · Ohio St. · 112 games | IND |
| 16 | Marlon Humphrey CB · Alabama · 4 Pro Bowls · 2 All-Pros · 131 games | BAL |
| 17 | Jonathan Allen DE · Alabama · 2 Pro Bowls · 126 games | WAS |
| 18 | CB · USC · 111 games | TEN |
| 21 | Jarrad Davis LB · Florida · 68 games | DET |
| 22 | Charles Harris OLB · Missouri · 103 games | MIA |
| 24 | Gareon Conley CB · Ohio St. · 31 games | OAK |
| 25 | Jabrill Peppers S · Michigan · 113 games | CLE |
| 26 | Takkarist McKinley DE · UCLA · 71 games | ATL |
| 27 | Tre'Davious White CB · LSU · 2 Pro Bowls · 1 All-Pro · 109 games | BUF |
| 28 | Taco Charlton DE · Michigan · 60 games | DAL |
| 30 | T.J. Watt OLB · Wisconsin · 8 Pro Bowls · 4 All-Pros · 135 games | PIT |
| 31 | Reuben Foster LB · Alabama · 16 games | SFO |
Source: nflverse draft_picks release. Pro Bowls / All-Pros / Games are career totals · ★ = Pro Football Hall of Fame.