Arizona Cardinals at San Francisco 49ers | Week 3, 2026

Arizona Cardinals at San Francisco 49ers | Week 3, 2026 | League Station

Heading In · Last 3 Games

Arizona Cardinals

0-3 SU

0-3 ATS1-2 O/U17.7 PPG33.3 OPG

San Francisco 49ers

2-1 SU

2-1 ATS2-1 O/U31 PPG26 OPG

Last 5 meetings · ARI 2–3 SFO SU

3-2 ATS (ARI)3-2 O/U

Date	Week	Result	ATS · O/U
2025-11-16· Wk 11	2025 Wk 11	SFO 41–22	MissOver
2025-09-21· Wk 3	2025 Wk 3	SFO 16–15	CoverUnder

Full matchup analysis

11-on-11 depth-chart breakdown, key positional edges, betting splits.