Week 16 · 2025 Season· FINAL
Date
Monday, December 22, 2025
Kickoff
8:15 PM
Location
Lucas Oil Stadium · Indianapolis, Indiana
Result
SFO 48 — IND 27
Betting Outcome
Spread
SFO covered −4
Total
Over 46.5 (75)
Heading In · Last 3 Games
San Francisco 49ers
3-0 · 27.7 PPG · 13.7 OPG- W37-24vs TEN
- W26-8@ CLE
- W20-9vs CAR
Indianapolis Colts
0-3 · 17 PPG · 24.7 OPG- L16-18@ SEA
- L19-36@ JAX
- L16-20vs HOU
Top Performers
San Francisco 49ers
- PassingBrock Purdy25/34, 295 yds, 5 TD, 1 INT
- RushingChristian McCaffrey21 att, 117 yds
- ReceivingGeorge Kittle7 rec, 115 yds, 1 TD
Indianapolis Colts
- PassingPhilip Rivers23/35, 277 yds, 2 TD, 1 INT
- RushingJonathan Taylor16 att, 46 yds, 1 TD
- ReceivingAlec Pierce4 rec, 86 yds, 2 TD
Recent Head-to-Head
Officials
- RefereeRonald Torbert#62
- UmpireBarry Anderson#20
- Down JudgeFrank LeBlanc#44
- Line JudgeBrian Bolinger#40
- Side JudgeKeith Washington#7
- Field JudgeRyan Dickson#25
- Back JudgeCourtney Brown#48