Round 1
| # | Player | Team |
|---|---|---|
| 3 | Joey Bosa DE · Ohio St. · 5 Pro Bowls · 122 games | SDG |
| 5 | Jalen Ramsey CB · Florida St. · 8 Pro Bowls · 3 All-Pros · 152 games | JAX |
| 7 | DeForest Buckner DE · Oregon · 3 Pro Bowls · 1 All-Pro · 151 games | SFO |
| 9 | Leonard Floyd OLB · Georgia · 153 games | CHI |
| 10 | Eli Apple CB · Ohio St. · 104 games | NYG |
| 11 | Vernon Hargreaves III CB · Florida · 69 games | TAM |
| 12 | Sheldon Rankins DT · Louisville · 133 games | NOR |
| 14 | Karl Joseph S · West Virginia · 65 games | OAK |
| 17 | Keanu Neal S · Florida · 1 Pro Bowl · 89 games | ATL |
| 19 | Shaq Lawson DE · Clemson · 110 games | BUF |
| 20 | Darron Lee OLB · Ohio St. · 58 games | NYJ |
| 24 | William Jackson III CB · Houston · 75 games | CIN |
| 25 | Artie Burns CB · Miami (FL) · 90 games | PIT |
| 27 | Kenny Clark DT · UCLA · 3 Pro Bowls · 157 games | GNB |
| 29 | Robert Nkemdiche DT · Mississippi · 38 games | ARI |
| 30 | Vernon Butler DT · Louisiana Tech · 77 games | CAR |
Source: nflverse draft_picks release. Pro Bowls / All-Pros / Games are career totals · ★ = Pro Football Hall of Fame.