San Francisco 49ers at Indianapolis Colts | Week 16, 2025 | League Station

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San Francisco 49ers at Indianapolis Colts | Week 16, 2025 | League Station

HomeScheduleSFO at IND

Week 16 · 2025 Season· FINAL

San Francisco 49ers

10-4 · NFC West

Final

Indianapolis Colts

8-6 · AFC South

Date

Mon, Dec 22, 2025

Week 16

Kickoff

8:15 PM ET

Location

Lucas Oil Stadium

Indianapolis, Indiana

Result

SFO 48, IND 27

Overview
Box Score
Team Stats
Play-by-Play
Madden Edge
Coaching

Coaching Matchup

San Francisco 49ers

Kyle ShanahanHead Coach
Klay KubiakOffensive Coordinator
Robert SalehDefensive Coordinator

Full impact report for SFO

Indianapolis Colts

Shane SteichenHead Coach
Jim Bob CooterOffensive Coordinator
Lou AnarumoDefensive Coordinator

Full impact report for IND