Week 1 · 2021 Season· FINAL
Date
Sun, Sep 12, 2021
Week 1
Kickoff
1:00 PM ET
Location
Ford Field
Detroit, Michigan
Result
SFO 41, DET 33
Coaching Matchup
San Francisco 49ers- Kyle ShanahanHead Coach
- Mike McDanielOffensive Coordinator
- DeMeco RyansDefensive Coordinator
Detroit Lions- Dan CampbellHead Coach
- Anthony LynnOffensive Coordinator
- Aaron GlennDefensive Coordinator